![]() To establish noninvasive models for LRF assessment based on liver stiffness measurement (LSM) and to evaluate their clinical performance.Ī total of 360 patients with compensated CLD were retrospectively analyzed as the training cohort. Even though its broad sickness classifications render it worthless in determining which patients should undergo a liver transplant first, it is nonetheless widely usedĪssessment of liver reserve function (LRF) is essential for predicting the prognosis of patients with chronic liver disease (CLD) and determines the extent of liver resection in patients with hepatocellular carcinoma. The Child-Pugh score does not take into account the etiology of cirrhosis, the possible combination of many causes, or the persistence of a destructive process such as persistent alcohol abuse or chronic hepatitis B infection (HBV). However, the Child-Pugh score is partly dependent on clinical examination, which may result in scoring differences. Although it was originally designed to predict mortality after surgery, the Child-Pugh score is today used to estimate prognosis, as well as the required strength of treatment and the need for liver transplantation. However, given their distinct benefits for some specific disorders, additional research may be required to identify the candidates who should use the Child-Pugh score for prognosis assessment and the timing when we should use the Child-Pugh score for prognosis assessment. In the majority of instances, Child-Pugh scores had similar prognostic relevance. We have reviewed all articles published from 1995-2022 comparing Child-Pugh score and MELD score for predicting prognosis in liver cirrhosis. This study provided an overview of the comparison of Child-Pugh scores for the assessment of prognosis in liver cirrhosis. Altogether, this study provides a new insight into the detailed molecular mechanisms of CPX as an anti-cancer therapy and a strategy for treating hepatocellular carcinoma. Interestingly, CPX could also induce glycogen clustering in HCC cells. Additionally, CPX could promote complete autophagic flux, which alleviated the anti-cancer effect of CPX in HCC cells, whereas the ROS scavenger (NAC) would attenuate CPX-induced protective autophagy. Moreover, the anti-cancer effects of CPX in HCC cells were also attributed to CPX-triggered ROS accumulation and DJ-1 downregulation. Here, we found that CPX could inhibit proliferation in HCC cells but not in intrahepatic cholangiocarcinoma cells by arresting the cell cycle. ![]() Ciclopirox olamine (CPX) is a synthetic antifungal agent and has been considered as an anti-cancer candidate drug recently, though the detailed mechanisms related to its anti-cancer effect in hepatocellular carcinoma have not yet been revealed. Thus far, the hepatocellular carcinoma prognosis has been bleak due to deficiencies in the identification and diagnosis of early hepatocellular carcinoma. Hepatocellular carcinoma is one of the most common fatal malignancies worldwide. ![]()
0 Comments
Leave a Reply. |